A writing interaction method, a smart interactive display device and a writing interaction system are provided. The writing interaction method includes: detecting a first touch event of one or more smart pens and acquiring one or more corresponding identifiers of the one or more smart pens (S100); generating handwriting according to the first touch event (S102A), and determining whether the generated handwriting corresponds to multiple smart pens of the smart pens according to the identifiers of the smart pens (S102B); under a condition that the handwriting corresponds to the multiple smart pens, generating multiple non-overlapping writing regions, wherein the multiple writing regions are in one-to-one correspondence with the multiple smart pens, each writing region covers handwriting of a corresponding smart pen, and each writing region only responds to a touch event of the corresponding smart pen for generating handwriting (S104).