A lockable package delivery locker at a publicly accessible location facilitates secure delivery by a delivery user of a package for later pickup by a recipient user. While the package is inside the locker a disinfection system disinfects the package and potentially its contents. A plurality of disinfection systems may provide different types of disinfection, including UV, chemical, nanotechnology, based on the type of packaging material. An electronic message may facilitate positioning UV emitters or chemical dispersion nozzles relative to the package. A locking mechanism and the disinfection system(s) may be controllable remotely from a server to which a computer device of the locker is in communication with, locally via an application on a UE device, or manually via an interface of the locker. The delivery user may be an individual shipping the package or a delivery service personnel, with the recipient user typically being the other.