A variable resistive memory device includes a memory cell, a first current-applying block, a second current-applying block and a mode setting circuit. The memory cell includes a first electrode, a second electrode, and a memory layer, the memory layer interposed between the first electrode and the second electrode. The first current-applying block is configured to flow a first current to the first electrode that flows from the first electrode to the second electrode. The second current-applying block is configured to flow a second current to the second electrode that flows from the second electrode to the first electrode. The mode setting circuit is configured to selectively provide any one of the first electrode of the first current-applying block and the second electrode of the second current-applying block with a first voltage. When the memory cell is selected, the selected current-applying block, among the first current-applying block and the second current-applying block, is driven. When the first current-applying block is selected, a second voltage is applied to the second electrode. When the second current-applying block is selected, the second voltage is applied to the first electrode. The first voltage has a voltage level by a threshold voltage higher than the second voltage.