A Class D power amplification modulation system for self-adaptive adjustment of an audio signal is provided, including an amplification circuit module, a pulse width modulation (PWM) circuit module connected to the amplification circuit module, a frequency detection circuit module, a carrier generator module connected to the frequency detection circuit module, an amplitude detection circuit module, a direct current (DC) potential adjustment module connected to the amplitude detection circuit module, and a drive circuit module. A method, a device, a processor, and a computer-readable storage medium are also provided. The characteristics of the circuit in the signal time domain and frequency are improved by simultaneously controlling the amplitude and the frequency of the audio signal, to minimize power consumption of signals with different amplitudes and frequencies, and to improve EMI performance, or to balance the circuit power consumption and EMI characteristics.