A patient interface system for positioning a patient's eye opposite a laser device for laser surgery is disclosed, including a patient interface for coupling to the patient's eye and a patient interface holder for arranging the patient interface on the laser device. The patient interface holder includes a holder device with an engaging device for reversibly coupling the patient interface to the patient interface holder, and to position the patient interface relative to the patient interface holder with a second positioning device. The engaging device has a spring-loaded engaging body that cooperates with an associated engaging surface of the second positioning device of the patient interface in the coupled state of the patient interface. A method for coupling a patient interface with a patient interface holder of a patient interface system, as well as a patient interface and a patient interface holder for a patient interface system are also disclosed.