The pneumatic therapy apparatus and method with overlapped compression include a wrap and a controller. The wrap includes an outer wrap and an inner air bladder set; the controller can be fixedly connected to, detachably connected to, or separately connected to the outer wrap; the inner air bladder set includes one or more than one set of a first air bladder and a second air bladder that are overlapped; the controller contains an inflating motor and an integrated control board that are electrically connected. The inflating motor that is controlled by the integrated control board inflates the second air bladder first and then the first air bladder to achieve the overlapped compression between the second air bladder and the first air bladder. Therefore, the user can use the pneumatic therapy apparatus and method with overlapped compression to promote blood flow, treat lymphedema, prevent deep vein thrombosis and other diseases, and improve user experience in the treatment areas.