Invention Grant
- Patent Title: GLP-1 analogues
-
Application No.: US17819466Application Date: 2022-08-12
-
Publication No.: US11866477B2Publication Date: 2024-01-09
- Inventor: Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
- Applicant: Sun Pharmaceutical Industries Limited
- Applicant Address: IN Maharashtra
- Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
- Current Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
- Current Assignee Address: IN Maharashtra
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: IN 1821013109 2018.04.05 IN 1821040468 2018.10.26 IN 1821040474 2018.10.26
- Main IPC: C07K14/605
- IPC: C07K14/605 ; A61K9/00 ; A61P3/10 ; A61P3/04 ; A61K38/00

Abstract:
The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
Public/Granted literature
- US20220402992A1 Novel GLP-1 Analogues Public/Granted day:2022-12-22
Information query