Invention Grant
- Patent Title: Oncolytic HSV vector
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Application No.: US16985459Application Date: 2020-08-05
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Publication No.: US11883448B2Publication Date: 2024-01-30
- Inventor: Hiroaki Uchida , Justus B. Cohen , Joseph C. Glorioso, III , Paola Grandi
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee Address: US PA Pittsburgh
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K35/763 ; C12N7/00 ; C07K14/005
Abstract:
The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
Public/Granted literature
- US20210138007A1 ONCOLYTIC HSV VECTOR Public/Granted day:2021-05-13
Information query
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