Invention Grant
- Patent Title: Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
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Application No.: US17343038Application Date: 2021-06-09
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Publication No.: US11884624B2Publication Date: 2024-01-30
- Inventor: Stephen Douglas Barrett , Fred Lawrence Ciske , Joseph Michael Colombo , Gregory William Endres , Bradlee David Germain , Andriy Kornilov , James Bernard Kramer , Adam Uzieblo , Kirk M. Maxey
- Applicant: Cayman Chemical Company, Inc.
- Applicant Address: US MI Ann Arbor
- Assignee: CAYMAN CHEMICAL COMPANY, INC.
- Current Assignee: CAYMAN CHEMICAL COMPANY, INC.
- Current Assignee Address: US MI Ann Arbor
- Agency: Barnes & Thornburg LLP
- Agent Ryan L. Marshall
- The original application number of the division: US16732537 2020.01.02
- Main IPC: C07D207/273
- IPC: C07D207/273 ; C07D207/26 ; C07D409/06 ; A61K31/4025 ; A61K31/4015 ; A61L24/00 ; A61L24/02 ; A61L27/12 ; A61L27/36 ; A61L27/54 ; A61L27/58
Abstract:
Disclosed herein are compounds of formula (I)
and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.
and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.
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Information query
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