Invention Grant
- Patent Title: Multi-chain chimeric polypeptides and uses thereof
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Application No.: US16952861Application Date: 2020-11-19
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Publication No.: US11884712B2Publication Date: 2024-01-30
- Inventor: Hing Wong
- Applicant: HCW Biologics, Inc.
- Applicant Address: US FL Miramar
- Assignee: HCW Biologics, Inc.
- Current Assignee: HCW Biologics, Inc.
- Current Assignee Address: US FL Miramar
- Agency: Fish & Richardson P.C.
- Main IPC: C07K14/54
- IPC: C07K14/54 ; C07K14/71 ; C07K14/715 ; C07K14/745 ; C07K16/28
Abstract:
Provided herein are multi-chain chimeric polypeptides that include:
(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.
(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.
Public/Granted literature
- US20210070826A1 MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF Public/Granted day:2021-03-11
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