Invention Grant
- Patent Title: Compositions and methods of phospholipase A2 receptor chimeric autoantibody receptor T cells
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Application No.: US17543429Application Date: 2021-12-06
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Publication No.: US11884716B2Publication Date: 2024-01-30
- Inventor: Saar Gill , Jonathan Hogan , Aimee S. Payne , Baomei Wang
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K35/17 ; C07K14/705 ; C07K14/725

Abstract:
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an anti-phospholipase A2 receptor (PLA2R) autoantibody-based B cell receptor, polynucleotides encoding the CAAR, vectors comprising a polynucleotide encoding the CAAR, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified cell, e.g., a genetically modified T cell, expressing a PLA2R-CAAR wherein the expressed CAAR comprises a PLA2R extracellular domain.
Public/Granted literature
- US20220098271A1 COMPOSITIONS AND METHODS OF PHOSPHOLIPASE A2 RECEPTOR CHIMERIC AUTOANTIBODY RECEPTOR T CELLS Public/Granted day:2022-03-31
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