- Patent Title: Antibodies which bind to glucagon-like peptide 1 receptor (GLP1R)
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Application No.: US17317056Application Date: 2021-05-11
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Publication No.: US11884736B2Publication Date: 2024-01-30
- Inventor: Haruka Okamoto , Jee H. Kim
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Fox Rothschild LLP
- Agent Liang Zeng Yan
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P3/08 ; A61K9/00 ; A61K39/00

Abstract:
The present disclosure relates to antibodies or antigen-binding fragments thereof that bind specifically to the glucagon-like peptide 1 receptor (GLP1R) protein, and methods of use thereof. In various embodiments, the antibodies or antigen-binding fragments thereof are fully human antibodies that bind to GLP1R. In some embodiments, the antibodies or antigen-binding fragments thereof are useful for attenuating GLP1R activity, thus providing a means of treating, preventing, or alleviating a disease, disorder or condition associated with GLP1R in humans. In some embodiments, the antibodies or antigen-binding fragments thereof elevate glucose levels when administered to a subject and thereby treat hypoglycemia, such as post-bariatric hypoglycemia (PBH), by attenuating insulin secretion from pancreatic beta cells and decreasing insulin expression.
Public/Granted literature
- US20210355227A1 ANTI-GLP1R ANTAGONIST ANTIBODIES AND METHODS OF USE THEREOF Public/Granted day:2021-11-18
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