Invention Grant
- Patent Title: Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
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Application No.: US17855543Application Date: 2022-06-30
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Publication No.: US11884944B2Publication Date: 2024-01-30
- Inventor: Tina Giese , Gunasekaran Kannan , Mihalis S. Kariolis , Cathal S. Mahon
- Applicant: DENALI THERAPEUTICS INC.
- Applicant Address: US CA South San Francisco
- Assignee: DENALI THERAPEUTICS INC.
- Current Assignee: DENALI THERAPEUTICS INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12N9/14 ; A61P3/00 ; A61K38/46
Abstract:
Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.
Public/Granted literature
- US20230062800A1 FUSION PROTEINS COMPRISING SULFOGLUCOSAMINE SULFOHYDROLASE ENZYMES AND METHODS THEREOF Public/Granted day:2023-03-02
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