A method for providing filtered air to a zone of a building includes operating an air handler to pass unfiltered air through a filter and output filtered air to the zone of the building. The method includes determining an amount of filtered air provided to the zone of the building by the air handler. The method includes determining if additional air filtration is required to satisfy at least one of a desired amount of clean airflow or a desired reduction of a risk of infection. The method includes activating an in-zone filtration device and operating the in-zone filtration device to draw air from the zone into an inner volume, filter the air, and recirculate the filtered air to the zone of the building in response to determining additional air filtration is required.