A chromatography valve for use in fluid analysis and chromatography applications is provided. The valve includes a first body having passages extending therethrough and opening on a flat face of the first body at respective passage ports. The valve also includes a second body engaged with the first body in a sealed relationship, whereby one of the first and second bodies is movable relative to the other one between two or more positions for controlling fluid circulation through the passages. The second body includes at least one cartridge receiving cavity for receiving at least one cartridge removably provided therein. The cartridge has channel(s) for channeling fluid of pairs of the passage ports, depending on the position of the first body relative to the second body, thereby channeling fluid through selected ones of the passages via the at least one channel. A method of operating the valve is also provided.