Systems and methods for managing host virtual addresses in a system call are disclosed. In one implementation, a processing device may receive, by a supervisor managing a first application), a system call initiated by the first application, wherein a first parameter of the system call specifies a memory buffer virtual address of the first application and a second parameter of the system call specifies the memory buffer virtual address of the second application. The processing device may also translate the memory buffer virtual address of the first application to a first physical address and may translate the memory buffer virtual address of the second application to a second physical address. The processing device may further compare the first physical address to the second physical address and responsive to determining that the first physical address matches the second physical address, the processing device may execute the system call using the memory buffer virtual address of the second application.