Methods, apparatus, and processor-readable storage media for determining storage system configuration recommendations based on vertical sectors and size parameters using machine learning techniques are provided herein. An example computer-implemented method includes obtaining data pertaining to multiple storage systems; segmenting, into one or more segments, the multiple storage systems based on one or more vertical sectors and one or more size parameters of an enterprise associated with each storage system; identifying, within each of the segments, each storage system running one or more vertical sector-specific applications; clustering, within each of the segments, the storage systems running one or more vertical sector-specific applications based on configuration information using at least one machine learning technique; generating one or more storage system configuration templates based on the clustering; and performing one or more automated actions based on the one or more generated storage system configuration templates.