Systems and methods to support an application that is voice-controlled are disclosed. Exemplary implementations may establish a synchronous two-way communication session between a first and a second user; present application information to the first and second user; detect first voice-control information from the first user and second voice-control information from the second user; control operations of the application based on the detected voice-control information; generate and/or determine results of the application based on the detected voice-control information; present the results to the users, and/or other steps.