A radio frequency identification (RFID) tag with a configurable anti-tamper structure includes an RFID chip electrically connected to a configurable anti-tamper structure. The configurable anti-tamper structure includes a plurality of conductive segments substantially oriented in a ladder configuration. At least some of the plurality of conductive segments are cut to leave a single conductive path in accordance to the desired tamper detection application, and the RFID tag is attached with the anti-tamper structure placed across a break point to be monitored for tampering. When tampering occurs, the conductive path is broken and the RFID chip changes the data sent in response to interrogation by an RFID reader.