Disclosed are computer systems and computer-implemented methods for rapid diagnostic test result interpretation platform employing computer vision. The system can visually analyze the test device in real-time by receiving image streams of the test device from the camera system. The detection system can be used to identify the test result in the test region. In some embodiments, the test result is binary (e.g., Positive/Negative). In some embodiments, the test result is in semi-quantitative formats (e.g., 1-10). The test result can be sent back to the user, operator, HMO, or physician for further confirmation, recording, and medical treatment decision/follow-up. The detection system can close the loop between the user of the test device and the HMO/physician for recording of the test result and the provision of medical treatment/follow-up.