A power distribution device, a power distribution trailer, an electric drive system and an operation method of the electric drive system are provided, the power distribution device includes: a starting power source, a switchgear room, and a tool room sequentially arranged along a first direction, the switchgear room includes a power inlet-line cabinet and a load feed outlet-line cabinet that are sequentially arranged along the first direction; at least one of the power inlet-line cabinet and the load feed outlet-line cabinet is a gas insulated switch cabinet, a cable terminal of at least one gas insulated switch cabinet is provided with a cable crimping copper bar, the gas insulated switch cabinet is matched with the cable crimping copper bar, a common cold shrinkable terminal connector can be combined with the cable crimping copper bar to realize the connection of an external device to the gas insulated switch cabinet through the cold shrinkable terminal connector.