A system, a method, and a computer program are provided for securely isolating access by one or more users in a group of network users to an enterprise network implementing Multi-Protocol Label Switching (MPLS). The security system includes an MPLS Layer-3 VPN (L3VPN) instance created for a group of users to be isolated, and a remote and mobile enterprise access (RMEA) gateway with secure socket layer virtual private network (SSL-VPN) and two-factor user authentication capabilities. A de-militarized zone (DMZ) is positioned in the network to security scan data traffic between the L3VPN and RMEA gateway. The security protocol involves two-factor user authentication and establishing, on top of the L3VPN instance, an SSL-VPN session between the user and the RMEA gateway, which provides the authorized user access to the network. Additionally, data traffic to/from the user is routed through the RMEA and the DMZ.