An ultrasonic surgical instrument includes a shaft assembly, an end effector, and a clamp arm driver. The shaft assembly includes a shaft portion extending along a first longitudinal axis, an articulation assembly, a distal shaft portion, and an ultrasonic waveguide extending through the proximal shaft portion, the articulation assembly, and the distal shaft portion. The articulation section is configured to deflect the end effector toward and away from the first longitudinal axis between a straight and articulated configuration. The end effector includes an ultrasonic blade defining a second longitudinal axis and a clamp arm configured to move between an open and closed configuration in order to grasp tissue. The clamp arm drive is configured to rotate the clamp arm relative to the ultrasonic blade about the second longitudinal axis and actuate the clamp arm between the open and closed configuration while the end effector is in the articulated configuration.