Invention Grant
- Patent Title: Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor
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Application No.: US16465750Application Date: 2017-12-11
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Publication No.: US11890300B2Publication Date: 2024-02-06
- Inventor: Dominik Lock , Mario Assenmacher , Andrew Kaiser
- Applicant: Miltenyi Biotec GmbH
- Applicant Address: DE Bergisch Gladbach
- Assignee: Miltenyi Biotec B.V. & Co. KG
- Current Assignee: Miltenyi Biotec B.V. & Co. KG
- Current Assignee Address: DE Bergisch Gladbach
- Agency: Fish & Richardson P.C.
- Agent Christian Biervert
- Priority: EP 204414 2016.12.15
- International Application: PCT/EP2017/082127 2017.12.11
- International Announcement: WO2018/108766A 2018.06.21
- Date entered country: 2019-05-31
- Main IPC: A61K35/15
- IPC: A61K35/15 ; C07K14/705 ; C07K14/725 ; A61K35/17 ; C07K16/28 ; C07K16/30 ; C12N5/0783
Abstract:
The present invention provides an immune effector cell that comprises a chimeric antigen receptor (CAR) specific for a tag of a tagged polypeptide, wherein said polypeptide binds to an antigen of a target cell, and a chimeric costimulatory receptor (CCR) specific for a further antigen. The CCR is not able to mediate said immune response on its own but boosts the immune response of said immune effector cell triggered by the CAR.
Public/Granted literature
- US20190388468A1 IMMUNE CELLS EXPRESSING AN ANTIGEN BINDING RECEPTOR AND A CHIMERIC COSTIMULATORY RECEPTOR Public/Granted day:2019-12-26
Information query
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