Invention Grant
- Patent Title: Methods and compositions for cells expressing a chimeric intracellular signaling molecule
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Application No.: US15754227Application Date: 2016-08-26
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Publication No.: US11890301B2Publication Date: 2024-02-06
- Inventor: Carl H. June , Michael Milone , Yangbing Zhao , Lawrence G. Lum , Archana Thakur
- Applicant: The Trustees of the University of Pennsylvania , Wayne State University
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania,Wayne State University
- Current Assignee: The Trustees of the University of Pennsylvania,Wayne State University
- Current Assignee Address: US PA Philadelphia; US MI Detroit
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle
- International Application: PCT/US2016/049087 2016.08.26
- International Announcement: WO2017/040324A 2017.03.09
- Date entered country: 2018-02-21
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C07K16/32 ; C12N15/09 ; A61K35/17 ; C07K16/28 ; A61P35/00 ; C07K14/705 ; C07K14/725 ; C12N5/0783 ; A61K35/00 ; A61K39/00

Abstract:
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and bispecific antibodies in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. Certain aspects include modified T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.
Public/Granted literature
- US20180243341A1 Methods and Compositions for Cells Expressing a Chimeric Intracellular Signaling Molecule Public/Granted day:2018-08-30
Information query
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