Invention Grant
- Patent Title: Aminomethyl-functionalized denatonium derivatives, their preparation and use
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Application No.: US16975077Application Date: 2019-02-20
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Publication No.: US11891352B2Publication Date: 2024-02-06
- Inventor: Lorenz Meinel , Tessa Luehmann , Martina Raschig
- Applicant: Julius-Maximilians-Universitaet Wuerzburg
- Applicant Address: DE Wuerzburg
- Assignee: Julius-Maximilians-Universitaet
- Current Assignee: Julius-Maximilians-Universitaet
- Current Assignee Address: DE Wuerzburg
- Agency: Smith Patent, LLC
- Agent Chalin A. Smith
- Priority: EP 157816 2018.02.21
- International Application: PCT/EP2019/054140 2019.02.20
- International Announcement: WO2019/162289A 2019.08.29
- Date entered country: 2020-08-21
- Main IPC: C07C237/04
- IPC: C07C237/04 ; C07C231/12 ; C07K1/10
Abstract:
The present invention is directed to compounds of the general formula (I) and salts thereof
wherein X− is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.
wherein X− is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.
Public/Granted literature
- US20210087138A1 AMINOMETHYL-FUNCTIONALIZED DENATONIUM DERIVATIVES, THEIR PREPARATION AND USE Public/Granted day:2021-03-25
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