Invention Grant
![3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors](/docs/US/2024-02-06/US11891365B2/abs.jpg.600x600.jpg)
- Patent Title: 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
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Application No.: US17238321Application Date: 2021-04-23
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Publication No.: US11891365B2Publication Date: 2024-02-06
- Inventor: Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair , David S. Millan , Matthew W. Martin
- Applicant: Valo Health, Inc.
- Applicant Address: US MA Boston
- Assignee: VALO HEALTH, INC.
- Current Assignee: VALO HEALTH, INC.
- Current Assignee Address: US MA Boston
- Agency: Dechert LLP
- Agent John P. Rearick; Nicholas J. Pace
- The original application number of the division: US16567007 2019.09.11
- Main IPC: A61K31/5513
- IPC: A61K31/5513 ; C07D267/14 ; C07D291/08 ; C07D413/06 ; C07D419/06 ; C07D413/12 ; C07D413/04 ; C07D267/12 ; C07D243/14 ; C07D401/06 ; C07D401/10 ; C07D403/06 ; C07D403/10 ; C07D405/06 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D498/04 ; C07D498/08 ; C07D493/08 ; C07D413/08 ; C07D491/107 ; C07D495/10
![3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors](/abs-image/US/2024/02/06/US11891365B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:
where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
Public/Granted literature
- US20220363651A1 3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS Public/Granted day:2022-11-17
Information query
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