Invention Grant
- Patent Title: Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof
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Application No.: US16606397Application Date: 2018-04-24
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Publication No.: US11891382B2Publication Date: 2024-02-06
- Inventor: Gregor Welti , Markus Heubes , David Tagliaferri
- Applicant: Basilea Pharmaceutica International AG
- Applicant Address: CH Basel
- Assignee: Basilea Pharmaceutica International AG
- Current Assignee: Basilea Pharmaceutica International AG
- Current Assignee Address: CH Basel
- Priority: EP 168283 2017.04.26 EP 172753 2017.05.24
- International Application: PCT/EP2018/060454 2018.04.24
- International Announcement: WO2018/197475A 2018.11.01
- Date entered country: 2019-10-18
- Main IPC: C07D413/04
- IPC: C07D413/04 ; C07C269/06 ; C07C271/06

Abstract:
The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula (I) and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula (I) and their use in the treatment of proliferative disorders.
Public/Granted literature
- US20210115032A1 PROCESSES FOR THE PREPARATION OF FURAZANOBENZIMIDAZOLES AND CRYSTALLINE FORMS THEREOF Public/Granted day:2021-04-22
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