Invention Grant
- Patent Title: Substituted macrocyclic indole derivatives
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Application No.: US17940617Application Date: 2022-09-08
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Publication No.: US11891404B2Publication Date: 2024-02-06
- Inventor: Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Rauh , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Katrin Nowak-Reppel , Sven Wittrock , David McKinney , Michael H. Serrano-Wu , Chris Lemke , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick Ryan McCarren , Rebecca Ann Harvey
- Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc.
- Applicant Address: DE MA Leverkusen
- Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.
- Current Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.
- Current Assignee Address: DE Leverkusen; DE Berlin; US MA Cambridge
- Agency: Foley Hoag LLP
- Agent David P. Halstead
- Main IPC: C07D498/14
- IPC: C07D498/14 ; A61P35/02 ; A61P35/00 ; A61K31/4162 ; A61K31/437 ; A61K31/496 ; A61K31/5377 ; A61K45/06 ; C07D471/22 ; C07D487/14 ; C07D487/22 ; C07D498/22
Abstract:
The present invention relates to substituted macrocyclic indole derivatives of general formula (I):
in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20230112244A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES Public/Granted day:2023-04-13
Information query
