An industrialization method for comprehensive utilization of Stevia rebaudiana. The major improvement is in that the Stevia rebaudiana is extracted by using a high-concentration alcohol solution, then the extracted solution is purified by using an organic solvent, and the pH of the extracted solution is adjusted to be alkaline according to the acidic characteristic of chlorogenic acid to enable the chlorogenic acid to be formed into a salt and have an increased polarity so as to achieve effective separation of the chlorogenic acid and a glucoside component in an adsorption process. The method allows the high-quality stevioside and chlorogenic acid to be obtained, significantly improves the comprehensive utilization rate of Stevia rebaudiana, reduces the waste of natural Stevia rebaudiana resources, reduces the resource consumption in a production process, reduces waste discharge, and is a high-benefit green production process.