• Patent Title: Antibodies with improved stability to intestinal digestion, polynucleotides thereof and methods of use thereof to treat disease
  • Application No.: US15765958
    Application Date: 2016-09-29
  • Publication No.: US11891440B2
    Publication Date: 2024-02-06
  • Inventor: Randall Edward Burton
  • Applicant: Circle33 LLC
  • Applicant Address: US WY Jackson
  • Assignee: CIRCLE33 LLC
  • Current Assignee: CIRCLE33 LLC
  • Current Assignee Address: US WY Jackson
  • Agency: HUESCHEN AND SAGE
  • International Application: PCT/US2016/054304 2016.09.29
  • International Announcement: WO2017/062253A 2017.04.13
  • Date entered country: 2020-09-24
  • Main IPC: A61K9/00
  • IPC: A61K9/00 A61K39/00 C07K16/24 A61P1/04
Antibodies with improved stability to intestinal digestion, polynucleotides thereof and methods of use thereof to treat disease
Abstract:
The present invention provides for recombinant antibodies having the features of ruminant early colostrum antibodies that impart resistance to proteases and intestinal digestion. It is a feature of the present invention that when administered to animals including humans, pharmaceutical compositions comprising the novel recombinant antibodies of the present invention, advantageously exhibit resistance to proteases and intestinal digestion. Thus, pharmaceutical compositions of the recombinant antibodies of the invention may be used to deliver antibody therapeutics particularly by oral delivery to the gastrointestinal tract when oral delivery is advantageous.
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