Invention Grant
- Patent Title: Glycosylation of variable immunoglobulin domains
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Application No.: US16612476Application Date: 2018-05-09
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Publication No.: US11891451B2Publication Date: 2024-02-06
- Inventor: Nico Callewaert , Bram Laukens , Loes Van Schie , Wander Van Breedam , Wim Nerinckx
- Applicant: VIB VZW , UNIVERSITEIT GENT
- Applicant Address: BE Ghent
- Assignee: VIB VZW,Universiteit Gent
- Current Assignee: VIB VZW,Universiteit Gent
- Current Assignee Address: BE Ghent; BE Ghent
- Agency: Patent Law Works LLP
- Priority: EP 170661 2017.05.11
- International Application: PCT/EP2018/062154 2018.05.09
- International Announcement: WO2018/206734A 2018.11.15
- Date entered country: 2019-11-11
- Main IPC: C07K16/40
- IPC: C07K16/40 ; A61K47/68
Abstract:
The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.
Public/Granted literature
- US20200148790A1 GLYCOSYLATION OF VARIABLE IMMUNOGLOBULIN DOMAINS Public/Granted day:2020-05-14
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