Invention Grant
- Patent Title: Fibers comprising polyesteramide copolymers for drug deliver
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Application No.: US17381320Application Date: 2021-07-21
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Publication No.: US11891726B2Publication Date: 2024-02-06
- Inventor: Mirian Hendrika Jacoba Gillisen-Van Der Vight , Jens Christoph Thies , Gueorgui Mihov
- Applicant: DSM IP Assets B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agent Kevin M. Bull
- Priority: EP 189803 2012.10.24 EP 166874 2013.05.07
- The original application number of the division: US16689569 2019.11.20
- Main IPC: D01F6/82
- IPC: D01F6/82 ; A61K47/34 ; A61K9/00 ; C08G69/44 ; C08L77/12 ; A61K9/70

Abstract:
The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV),
wherein
m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9;
m+p+q=1 whereby m or p could be 0;
n is about 5 to about 300; (pref. 50-200);
—R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11—, and combinations thereof;
—R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2, CH═C—CH2, HO-p-Ph-CH2, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—;
—R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol;
—R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III);
—R7 is selected from the group consisting of (C6-C10)aryl(C1-C6)alkyl;
—R8 is —(CH2)4—;
—R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene; and
—R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.
wherein
m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9;
m+p+q=1 whereby m or p could be 0;
n is about 5 to about 300; (pref. 50-200);
—R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11—, and combinations thereof;
—R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2, CH═C—CH2, HO-p-Ph-CH2, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—;
—R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol;
—R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III);
—R7 is selected from the group consisting of (C6-C10)aryl(C1-C6)alkyl;
—R8 is —(CH2)4—;
—R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene; and
—R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.
Public/Granted literature
- US20220002912A1 FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVER Public/Granted day:2022-01-06
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