A refrigeration system for a temperature-controlled storage device includes a refrigeration circuit that circulates a refrigerant, a separate cooling circuit that circulates a coolant, and a controller. The refrigeration circuit includes a compressor, a condenser, an expansion device, and an evaporator. The cooling circuit includes a pump, a control valve, and a heat removing device in fluid communication with the condenser via the coolant. The controller is operatively coupled to the control valve and configured to identify a coolant temperature differential setpoint, monitor a temperature of the coolant provided to the condenser by the cooling circuit, calculate a coolant temperature differential based on the temperature of the coolant provided to the condenser, and operate the control valve to modulate a flow of the coolant through the condenser to drive the coolant temperature differential to the coolant temperature differential setpoint.