Invention Grant
- Patent Title: Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis
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Application No.: US16629054Application Date: 2018-07-05
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Publication No.: US11892457B2Publication Date: 2024-02-06
- Inventor: Dax Fu , Chengfeng Merriman , Hongjie Dai , Hao Wan
- Applicant: THE JOHNS HOPKINS UNIVERSITY , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Johns Hopkins University,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US MD Baltimore; US CA Stanford
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2018/040890 2018.07.05
- International Announcement: WO2019/014044A 2019.01.17
- Date entered country: 2020-01-07
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/564 ; G01N21/64
Abstract:
Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.
Information query
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