The present disclosure relates to the field of analog integrated circuit technology. A digital and analog mixed signal control circuit for eliminating a degenerate metastable state of a self-biased bandgap reference circuit utilizes a digital-to-analog converter module with low-power consumption and flexibly customized accuracy as needed, a delay switch, and a non-volatile memory cell to directly control and clamp a circuit node at the degenerate metastable state in the bandgap reference circuit module, and to release the clamping after a certain delay. Such control mechanism effectively prevents the self-biased bandgap reference circuit with an operational amplifier from entering the degenerate metastable state, and enhance robustness of the circuit, such that the reference circuit is capable of starting normally under various conditions, which improves the performance and yield of the products.