Snapshots may be used to implement remote replication, for example, asynchronously, between a first storage system, A1, and a second storage system, A2. A1 may take a first snapshot, SS21, of a logical storage unit, R1. After the snapshot SS21 it taken, any dependent write operations associated with SS21 may be reconciled, and differences between SS21 and the last snapshot for R1, SS11, may be determined and recorded as a difference set. One or more replication instructions for R1 that include the write operations (or data and metadata corresponding thereto) of the difference set may be sent from A1 to A2. A2 may apply the differences to R2, and then take (activate) a snapshot of R2, SS22, which is a replica of SS21. After A2 activates SS22, A2 may send an acknowledgement to A1 indicating that SS22 has been activated, and A2 may take a next snapshot of R1.