A method and system of optimizing pressure regulation at an intelligent gas gate station based on an Internet of Things are provided. The method is performed by an intelligent gas management platform, and the intelligent gas management platform includes an intelligent customer service management sub-platform, an intelligent operation management sub-platform, and an intelligent gas data center, the method includes: obtaining, by the intelligent gas data center, gas terminal information from an intelligent gas object platform through the intelligent gas sensor network platform, wherein the gas terminal information includes gas terminal flow and a gas terminal distribution feature; predicting, by the intelligent operation management sub-platform, gas gate station flow based on the gas terminal information; and determining, by the intelligent operation management sub-platform, a pressure regulation scheme of the gas gate station based on the gas gate station flow.