Computer-implemented method, systems, computer program products include a processor(s) that obtains input data comprising an image and image data: coordinates (points) defining a region of interest in the image. The processor(s) determines a non-duplicative sequential order for navigating the coordinates. The processor(s) defines a set of points bordering the region of interest: points in the image and points comprising intersection points between two coordinates with an edge of a pixel in the image. The processor(s) determines a combined area of sub pixel subregions in each pixel that includes points in the set of points by: identifying the points of the set, generating one or more sub pixel subregions, and utilizing the sub pixel subregions to determine the combined area of sub pixel subregions.