A display panel and a driving method thereof, and a display device are provided. The display panel includes a first display region, a second display region, and a control device. The first display region is on a side of the second display region, and the second display region includes N display sub-regions; and the control device is connected to the first display region and the second display region, respectively, and configured to control display of the first display region and display of the second display region in i time intervals within one frame period, and sequentially control the display of the first display region and display of an i-th display sub-region in the second display region in an i-th time interval, wherein 1≤i≤N, and N is a positive integer greater than or equal to 3.