Disclosed are a readout circuit, a signal quantizing method, a signal quantizing device, and a computer device. The readout circuit includes: a signal sampler, including a plurality of channels; a plurality of integrators, connected to the plurality of channels and having a one-to-one relationship with the plurality of channels; a signal processor, including a first operational amplifier, a sampling input of the first operational amplifier being connected to outputs of the plurality of integrators, respectively; and an analog-digital converter. An input of the analog-digital converter is connected to an output of the first operational amplifier.