The disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. The UE first transmits a first radio signal, and then transmits a second radio signal; wherein the first radio signal includes M1 first radio sub-signal(s), and a first sequence is used for generating the first radio sub-signal; the second radio signal includes M2 second radio sub-signal(s), and a first bit block is used for generating the second radio sub-signal; the M1 is a positive integer, the M2 is a positive integer in a target set, and each element in the target set is a positive integer; and the target set is correlated with at least one of the M1 or the first sequence. The disclosure can save overheads caused by control information and improve spectrum efficiency of uplink transmission.