Invention Grant
- Patent Title: sGC stimulators
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Application No.: US16955494Application Date: 2018-12-19
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Publication No.: US11897887B2Publication Date: 2024-02-13
- Inventor: Glen Robert Rennie , Paul Allan Renhowe , Takashi Nakai , Ara Mermerian , Helen Cumberbatch
- Applicant: Tisento Therapeutics Inc.
- Applicant Address: US MA Cambridge
- Assignee: Tisento Therapeutics Inc.
- Current Assignee: Tisento Therapeutics Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Xin Zhang; James M. Alburger
- International Application: PCT/US2018/066547 2018.12.19
- International Announcement: WO2019/126354A 2019.06.27
- Date entered country: 2020-12-16
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07F9/09 ; A61K45/06

Abstract:
The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts, pharmaceutical formulations comprising them as well as their phosphate ester prodrugs, and their uses alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or the upregulation of the NO pathway is desirable. The compounds are of Formula I.
Public/Granted literature
- US20200377508A1 sGC STIMULATORS Public/Granted day:2020-12-03
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