Invention Grant
- Patent Title: In vitro generation of thymic organoid from human pluripotent stem cells
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Application No.: US16648008Application Date: 2018-09-19
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Publication No.: US11898166B2Publication Date: 2024-02-13
- Inventor: Raul E. Vizcardo , Nicholas P. Restifo
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2018/051625 2018.09.19
- International Announcement: WO2019/060336A 2019.03.28
- Date entered country: 2020-03-17
- Main IPC: C12N5/078
- IPC: C12N5/078 ; A61K35/26
Abstract:
Disclosed are methods of preparing thymic organoids according to embodiments of the invention. Also disclosed are methods of preparing thymic emigrant cells in vitro, according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e g., cancer.
Public/Granted literature
- US20200270571A1 IN VITRO GENERATION OF THYMIC ORGANOID FROM HUMAN PLURIPOTENT STEM CELLS Public/Granted day:2020-08-27
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