Examples of the present disclosure describe systems and methods for dynamically expanding acronyms in audio content. In aspects, a user access of an audio resource may be detected. The audio content of the audio resource may be evaluated to identify acronyms. One or more of the identified acronyms may be evaluated based on a user-specific context of the user and/or a global context associated with the user. Based on the evaluated context(s), expansion candidates and corresponding confidence scores may be determined for each identified acronym. Based on the confidence scores, an expansion candidate may be selected and used to replace the identified acronym when the audio content is consumed by the user.