A big data artificial intelligence computer system is used for medical care connecting to sensor-equipped smartphones of users of footwear. The footwear has smartphone-connected soles with sensors and configurable structures. The smartphone is also connected to sensors located on the users' body, including proximate to its center of gravity and/or on the head. The web and/or cloud-based computer system is configured to use the big data techniques of machine learning in a database compiled from millions of smartphones to perform operations on billions of data sets from the smartphones of the footwear users. The correlations found from the big data operations provide solutions to medical problems of the footwear users involving their body structure and/or function. The solutions are implemented by configuring the users' footwear soles, including active configuration, including during running and/or walking to optimize corrections to the structure and/or function of their bodies.