PCIe devices installed in host computers communicating with service nodes can provide virtualized NVMe over fabric services. A workload on the host computer can submit an SQE on a NVMe SQ. The PCI device can read the SQE to obtain a command identifier, an OpCode, and a namespace identifier (NSID). The SQE can be used to produce a LTP packet that includes the opcode, the NSID, and a request identifier. The LTP packet can be sent to the service node, which may access a SAN in accordance with the opcode and NSID, and can respond to the LTP with a second LTP that includes the request identifier and a status indicator. The PCI device can use the status indicator and the request identifier to produce a CQE that is placed on a NVMe CQ associated with the SQ.