An imaging device positioning system for monitoring an anatomical region (10). The imaging device positioning system employs an imaging device (20) for generating an image (21) of an anatomical region (10). The imaging device positioning system further employs an imaging device controller (30) for controlling a positioning of the imaging device (20) relative to the anatomical region (10). During a generation by the imaging device (20) of the image (21) of the anatomical region (10), the imaging device controller (30) adapts the positioning of the imaging device (20) relative to the anatomical region (10) to a physiological condition of the anatomical region (10) extracted from the image (21) of the anatomical region (10).