Invention Grant
- Patent Title: Use of a combinational therapy of LSD1 inhibitors with P21 activators in the treatment of cancer
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Application No.: US16608003Application Date: 2018-04-25
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Publication No.: US11918580B2Publication Date: 2024-03-05
- Inventor: Saverio Minucci , Pier Giuseppe Pelicci , Seyed Amir Hosseini
- Applicant: Istituto Europeo di Oncologia S.r.l. , Università degli Studi Di Milano
- Applicant Address: IT Milan
- Assignee: Istituto Europeo di Oncologia S.r.l.,Università degli Studi Di Milano
- Current Assignee: Istituto Europeo di Oncologia S.r.l.,Università degli Studi Di Milano
- Current Assignee Address: IT Milan; IT Milan
- Agency: COOLEY LLP
- Agent Heidi A. Erlacher; Thomas J. Paxton
- International Application: PCT/EP2018/060637 2018.04.25
- International Announcement: WO2018/197583A 2018.11.01
- Date entered country: 2019-10-24
- Main IPC: A61P35/00
- IPC: A61P35/00 ; A61K31/135 ; A61K31/165 ; A61K31/167 ; A61K31/18 ; A61K31/325 ; A61K31/343 ; A61K31/366 ; A61K31/4025 ; A61K31/4045 ; A61K31/407 ; A61K31/4155 ; A61K31/4184 ; A61K31/437 ; A61K31/44 ; A61K31/4406 ; A61K31/4439 ; A61K31/445 ; A61K31/47 ; A61K31/473 ; A61K31/495 ; A61K31/496 ; A61K31/506 ; A61K31/519 ; A61K31/5375 ; A61K31/549 ; A61K38/15 ; A61P35/02
Abstract:
The present disclosure relates to methods of treating cancer and pharmaceutical compositions for use in the treatment of cancer, including LSD1-inhibitor-resistant cancers, comprising administering to a subject an effective amount of a cell cycle inhibitor, such as a CDK4/6 inhibitor or a p21 enhancer, and an effective amount of a LSD1 inhibitor.
Public/Granted literature
- US20210100800A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER Public/Granted day:2021-04-08
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
