Invention Grant
- Patent Title: Low concentrated protein compositions for preventing tissue adhesion
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Application No.: US16710541Application Date: 2019-12-11
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Publication No.: US11918629B2Publication Date: 2024-03-05
- Inventor: Israel Nur , Elena Grimberg , Itai Podoler , Inbar Gahali-Sass , Erez Ilan , Ronen Eavri
- Applicant: Omrix Biopharmaceuticals Ltd.
- Applicant Address: IL Rehovot
- Assignee: Omrix Biopharmaceuticals Ltd.
- Current Assignee: Omrix Biopharmaceuticals Ltd.
- Current Assignee Address: IL Rehovot
- Agent David R. Crichton
- Priority: IL 3679 2018.12.12
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K9/08 ; A61K33/06 ; A61K38/36 ; A61K38/37 ; A61K38/38 ; A61K38/48 ; A61P7/04 ; A61P41/00

Abstract:
Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.
Information query
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